Certified Safety
Fully MDR certified with ultra-pure HA
Croma Saypha® Hyaluronic Acid Fillers
Saypha® is the flagship hyaluronic acid dermal filler from Croma-Pharma, Austria's leading pharmaceutical innovator with over 50 years of expertise. As the first HA filler to achieve full EU MDR certification, Saypha® sets the gold standard for safety, efficacy, and regulatory compliance in aesthetic medicine.
Powered by MACRO Core Technology, Saypha® delivers optimal tissue integration and natural-looking results. Its ultra-pure formulation contains less than 2 ppm BDDE residuals and boasts an exceptional 0.005% complaint rate, reflecting unparalleled quality control and patient satisfaction.
ComfortFlow Syringe
Premium glass syringe for precise control
Long-Lasting Results
Results lasting up to 9-12 months
Austrian Manufacturing
50 years of pharmaceutical expertise
Choose the right filler
Compare the Saypha® range
Four lidocaine formulations, each engineered for a specific depth and indication.
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|---|---|---|---|---|
| Indicated for | Light to moderate nasolabial folds | Moderate to severe nasolabial folds | Moderate to severe midface volume loss | Lip augmentation |
| Injection depth | Mid to deep dermis | Deep dermis, subcutis, supraperiosteal | Deep subcutaneous, supraperiosteal | Submucosa |
| HA concentration | 23 mg/mL | 23 mg/mL | 25 mg/mL | 23 mg/mL |
| Lidocaine | 0.3% | 0.3% | 0.3% | 0.3% |
| Results | Up to 9 months | Up to 9 months | 78% still satisfied at 12 months | Up to 9 months |
| Clinical highlight | 93% satisfaction at 9 months | 95% improved at week 4 | 96% satisfaction at 4 weeks | 99.1% pleased with the result |
| Health Canada licence | #98900 | #97878 | #106387 | #115506 |
| View | View | View | View |
- Indicated for
- Light to moderate nasolabial folds
- Injection depth
- Mid to deep dermis
- HA concentration
- 23 mg/mL
- Lidocaine
- 0.3%
- Results
- Up to 9 months
- Clinical highlight
- 93% satisfaction at 9 months
- Health Canada licence
- #98900
- Indicated for
- Moderate to severe nasolabial folds
- Injection depth
- Deep dermis, subcutis, supraperiosteal
- HA concentration
- 23 mg/mL
- Lidocaine
- 0.3%
- Results
- Up to 9 months
- Clinical highlight
- 95% improved at week 4
- Health Canada licence
- #97878
- Indicated for
- Moderate to severe midface volume loss
- Injection depth
- Deep subcutaneous, supraperiosteal
- HA concentration
- 25 mg/mL
- Lidocaine
- 0.3%
- Results
- 78% still satisfied at 12 months
- Clinical highlight
- 96% satisfaction at 4 weeks
- Health Canada licence
- #106387
- Indicated for
- Lip augmentation
- Injection depth
- Submucosa
- HA concentration
- 23 mg/mL
- Lidocaine
- 0.3%
- Results
- Up to 9 months
- Clinical highlight
- 99.1% pleased with the result
- Health Canada licence
- #115506
All Saypha® fillers contain 0.3% lidocaine, BDDE ≤ 2 ppm, 1.0 mL steam-sterilized syringes and include 2 × 27G ½″ Terumo™ needles. For licensed healthcare professionals only. Always refer to the official IFU.
Treatment map
One portfolio, every indication.
Select an area to see which Saypha® formulation is indicated, with its injection depth, HA concentration and duration.
Indications as licensed by Health Canada. For licensed healthcare professionals only.
New · Regenerative
Exprecell. Regeneration in a single syringe.
An all-in-one system by Croma-Pharma for fast, anticoagulant-free preparation of autologous PRP and Fluid-PRF. Blood aspiration and processing happen in one closed, high-capacity syringe, for fewer steps and a lower contamination risk.
- 5min
- single-spin protocol at approx. 420 × g
- 8.5mL
- of PRP or Fluid-PRF from 18 mL of whole blood
- >99%
- erythrocyte depletion, with approx. 95% leukocyte depletion
- 2.3×
- platelet concentration above baseline
Needle Concept
Mesbio Needle
Premium medical-grade needles designed for precision aesthetic treatments. Engineered in France with ultra-thin walls for optimal flow and minimal trauma.
- ISO 13485
- Medical Device Class IIa
- Box of 100 needles
- Sterile blister packaging
- Single-use, disposable
Face
Precision facial treatments
Hair
Hair restoration therapy
Body
Body contouring applications
Made in France
Medical-grade quality
Technical Specifications
| Gauge (Color) | Diameter | Available Lengths |
|---|---|---|
| 27G | Ø 0.40 mm | 4 mm, 8 mm, 12 mm |
| 30G | Ø 0.30 mm | 4 mm, 8 mm, 12 mm |
| 31G | Ø 0.25 mm | 4 mm, 8 mm, 12 mm |
| 32G | Ø 0.23 mm | 4 mm, 8 mm, 12 mm |
| 33G | Ø 0.20 mm | 4 mm, 8 mm, 12 mm |
| 34G | Ø 0.18 mm | 4 mm, 8 mm, 12 mm |
Needle Concept
Magic Needle Cannula
Premium medical-grade cannulas designed for precision aesthetic procedures with minimal patient discomfort and optimal results.
- Flexible Blunt-Tip Design
- Innovative Surface Treatment
- Luer-Lock Compatibility
- ISO 13485 Certified
- Medical Device Class IIa
- Box of 25 kits
- Sterile blister packaging
Face & Body Applications
Natural Homogeneous Results
Less Bruising & Pain
Single-Point Injection Coverage
Technical Specifications
| Product | Cannula Specifications | Pilot Needle Included |
|---|---|---|
| 14G-90MM | Cannula 14G 90 (Ø2.10 x 90mm) | Pilot needle 14G 12 (Ø2.10 x 12mm) |
| 16G-70MM | Cannula 16G 70 (Ø1.60 x 70mm) | Pilot needle 15G 12 (Ø1.80 x 12mm) |
| 16G-90MM | Cannula 16G 90 (Ø1.60 x 90mm) | Pilot needle 15G 12 (Ø1.80 x 12mm) |
| 18G-70MM | Cannula 18G 70 (Ø1.20 x 70mm) | Pilot needle 17G 12 (Ø1.40 x 12mm) |
| 18G-90MM | Cannula 18G 90 (Ø1.20 x 90mm) | Pilot needle 17G 12 (Ø1.40 x 12mm) |
| 20G-70MM | Cannula 20G 70 (Ø0.90 x 70mm) | Pilot needle 19G 12 (Ø1.10 x 12mm) |
| 20G-90MM | Cannula 20G 90 (Ø0.90 x 90mm) | Pilot needle 19G 12 (Ø1.10 x 12mm) |
| 22G-57MM | Cannula 22G 57 (Ø0.70 x 57mm) | Pilot needle 21G 12 (Ø0.80 x 12mm) |
| 22G-70MM | Cannula 22G 70 (Ø0.70 x 70mm) | Pilot needle 21G 12 (Ø0.80 x 12mm) |
| 22G-90MM | Cannula 22G 90 (Ø0.70 x 90mm) | Pilot needle 21G 12 (Ø0.80 x 12mm) |
| 25G-40MM | Cannula 25G 40 (Ø0.50 x 40mm) | Pilot needle 23G 12 (Ø0.60 x 12mm) |
| 25G-50MM | Cannula 25G 50 (Ø0.50 x 50mm) | Pilot needle 23G 12 (Ø0.60 x 12mm) |
| 25G-60MM | Cannula 25G 60 (Ø0.50 x 60mm) | Pilot needle 23G 12 (Ø0.60 x 12mm) |
| 27G-37MM | Cannula 27G 37 (Ø0.40 x 37mm) | Pilot needle 26G 12 (Ø0.45 x 12mm) |
| 30G-27MM | Cannula 30G 27 (Ø0.30 x 27mm) | Pilot needle 27G 12 (Ø0.40 x 12mm) |
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